Investigation Service
Laboratory Division
Confocal Laser Scanning Microscope (CLSM)
Confocal laser scanning microscope broadly applied in biological studies ranging from cellular biology, genes, and also macromolecular biology. Especially for applications that require high-resolution images and the ability to capture only the focus area and specify the required sample layer depth.
Leica TCS SP5 II Confocal
Leica TCS SP5 II Confocal
Thick Specimen imaging
cell culture, tissue sample from human, animal or plants
Live cell imaging
Developmental study, expression over time-lapse study, pharmacokinetic study, Human or Animal Fertilization study
3D imaging
2D & 3D imaging, 3D time-lapse (4D) imaging
Multi-dyes immune-labeling imaging
Co-localization study, Immunocytochemistry, Immunohistochemistry, cell-signaling study, protein-labeling expression
Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS)
Liquid chromatography-mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). This technique is very specific and useful for analyzing non-separable or partial mixtures. The analysis results were shown in the form of the relationship between the time required for the substance to pass through the column and the absorbance or the graph showing Relative abundance to confirm the analytical.
- Application:
- Structural analysis of natural products: Thai herbs
- Drug analysis for Pharmacokinetics, Bioavailability, and Bioequivalence Studies
- Pollutants analysis in food and environment
AGILENT TECHNOLOGIES 123035 LC-MS/MS
Real-Time PCR
Real-time PCR is an advanced instrument used to amplify DNA sequences that examine the amount of DNA/cDNA that can be increased at each cycle while the reaction is ongoing, which has a fluorescent signal.
- Application:
- Quantitation of gene expression
- Pathogen detection
- Genotype/Allelic discrimination
- Microsatellite analysis
- Single nucleotide polymorphism detection
Roche LightCycler® 480 System
ABI 7500/7500 Real-Time PCR System
ABI StepOne Real-Time PCR Systems
Flow Cytometer
Flow Cytometry is a technique for detecting and identifying physical and chemical characteristics of a population of cells or particles such as cell size, complexity of intracellular components, protein or substance analysis.
- Application:
- Leukemia and hematocystic identification for chemotherapy treatments
- Basophil activation test for allergen
- Study of cancer cell apoptosis and cell cycle
- Diagnosis of primary immunodeficiency of T and B cell defect, by lymphocyte counting and neutrophil function test
BD FACSVerse™
Ultra High Pressure Liquid Chromatography (UHPLC)
UHPLC is similar to HPLC, in that it is a technique used to separate different constituents of a compound. The different technique is UHPLC used shorter column, less quantity of substance analyzed used, reduced time, and reduced the number of chemicals used as the moving phase in the analysis providing better separation.
UltiMate 3000 HPLC and UHPLC Systems
- Application:
- Drug analysis
- Determination of types and quantity of sugar in extracts
- Analysis of composition of medicinal extracts
- Analysis of pesticide residues in fruit and vegetable samples
- Quantitative analysis of narcotics and various toxic substances